Jie Jack Li

For the world's largest prescription drug manufacturers, the last few years have been a harrowing time. Recently, Pfizer's Lipitor, GlaxoSmithKline's Advair, AstraZeneca's Seroquel, and Sanofi-Aventis and Bristol-Myers Squibb's Plavix all came off patent in the crucial U.S. market. This so-called "patent cliff" meant hundreds...

It's time to examine the human history of viruses, vaccines, and antiviral drugs...Public response to the COVID-19 pandemic has demonstrated that misinformation about viruses is widespread. Vaccine skepticism is rampant, and many people have been quick to accept bogus claims unsupported by science. In...

Current Drug Synthesis The latest entry in the widely read Drug Synthesis series In Current Drug Synthesis, accomplished medicinal chemist and researcher Dr. Jie Jack Li and 27 expert coauthors deliver an authoritative and comprehensive discussion of the medicinal chemistry of current drugs, as...

Drug Discovery with Privileged Building Blocks traces back PharmaBlock's founding philosophy of designing privileged building blocks. High-quality building blocks are crucial not only to biological activities of different molecules but also to ADMET properties, which eventually will impact the success rate of drug discovery...

An integrated and insightful look at successful drug synthesis in today's drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages...

This book covers all aspects of the medicinal chemistry of the latest drugs, and the cutting-edge science associated with them. Following the editors' 3 successful drug synthesis books, this provides expert analysis of the pros and cons of different synthetic routes and demystifies the...

The stories behind drug discovery are fascinating, full of human and scientific interest. This is a book on the history of drug discovery that highlights the intellectual splendor of discoverers as well as the human frailty associated them. History is replete with examples of...

Presenting both a panoramic introduction to the essential disciplines of drug discovery for novice medicinal chemists as well as a useful reference for veteran drug hunters, this book summarizes the state-of-the-art of medicinal chemistry. It covers key drug targets including enzymes, receptors, and ion...

Searching for reaction in organic synthesis has been made much easier in the current age of computer databases. However, the dilemma now is which procedure one selects among the ocean of choices. Especially for novices in the laboratory, it becomes a daunting task to...

Searching for reaction in organic synthesis has been made much easier in the current age of computer databases. However, the dilemma now is which procedure one selects among the ocean of choices. Especially for novices in the laboratory, it becomes a daunting task to...

Author: Jie Jack LiISBN-10: 0470085088ISBN-13: 9780470085080Publisher: WileyLanguage: EnglishPublished: 09/13/2011Pages: 704Format: HardcoverWeight: 3.25lbsSize: 9.30h x 7.20w x 1.60dReview Citation(s): Choice 05/01/2012

This practical, well-organized reference delves deeply into functional group transformations, to provide all the detailed information that researchers need. Topics are organized into the following sections: oxidation, reduction, asymmetric synthesis, and functional group manipulations Each section includes a description of the functional group transformation,...

The third edition of this book on name reactions contains major improvements over the previous edition. In addition to updated references, each reaction is now supplemented with two to three representative examples in synthesis to showcase its synthetic utility. Biographical sketches for the chemists...

From the content: Alder ene reaction.-Aldol condensation.-Algar-Flynn-Oyamada reaction.-Allan-Robinson reaction.-Arndt-Eistert homologation.-Baeyer-Villiger oxidation.-Baker-Venkataraman rearrangement.-Bamford-Stevens reaction.-Baran reagents.-Barbier reaction.-Bargellini reaction.-Bartoli indole synthesis.-Barton radical decarboxylation.-Barton-McCombie deoxygenation.-Barton nitrite photolysis.-Barton-Zard reaction.-Batcho-Leimgruber indole synthesis.-Baylis-Hillman reaction.-Beckmann rearrangement.-Abnormal Beckmann rearrangement.-Beirut reaction.-Benzilic acid rearrangement.-Benzoin condensation.-Bergman cyclization.-Biginelli reaction.-Birch reduction.-Bischler-Mlau indole synthesis.-Bischler-Napieralski reaction.-Blaise reaction.-Blum-Ittah aziridine synthesis.-Boekelheide reaction.-Boger...

This book covers over 320 classical as well as contemporary name reactions. Each reaction is delineated by its detailed step-by-step, electron-pushing mechanism and supplemented with references. This fifth edition adds 27 new name reactions.Author: Jie Jack LiISBN-10: 3030508641ISBN-13: 9783030508647Publisher: SpringerLanguage: EnglishPublished: 01/29/2021Pages: 601Format: HardcoverWeight:...

Drugs like Lipitor, Plavix, Taxol, and Zoloft are integral in today's medicinal world. These widely used products save lives and improve the quality of lives, playing a crucial role in everything from cholesterol management to cancer treatment. These advances in medicine were brought into...

Nominine.- Nakiterpiosin: A Novel C-nor-D-homosteroid.- The Kinamycins.- A Short Synthesis of Strychinine from Pyridine.- Bryostatin 7.- Serratezomine A.- Hypocrellin/Cercosporin.- Total Synthesis of Phomactin A.- (+)-11,11'-Dideoxyverticillin A.- Retigeranic Acid.- Companadine A.Author: Jie Jack LiISBN-10: 3642440924ISBN-13: 9783642440922Publisher: SpringerLanguage: EnglishPublished: 04/12/2015Pages: 279Format: PaperbackWeight: 0.92lbsSize: 9.21h x 6.14w...