{"product_id":"a-guide-to-sample-size-penny-s-reynolds-9781119799979","title":"A Guide to Sample Size for Animal-Based Studies","description":"\u003cb\u003eA Guide to Sample Size for Animal-based Studies\u003c\/b\u003e \u003cp\u003e\u003cb\u003eUnderstand a foundational area of experimental design with this innovative reference\u003c\/b\u003e \u003c\/p\u003e\u003cp\u003eAnimal-based research is an essential part of basic and preclinical research, but poses a unique set of experimental design challenges. The most important of these are the 3Rs - Replacement, Reduction and Refinement - the principles comprising the ethical framework for humane animal-based studies. However, many researchers have difficulty navigating the design trade-offs necessary to simultaneously minimize animal use, and produce scientific information that is both rigorous and reliable. \u003c\/p\u003e\u003cp\u003e\u003ci\u003eA Guide to Sample Size for Animal-based Studies\u003c\/i\u003e meets this need with a thorough, accessible reference work to the subject. This book provides a straightforward systematic approach to \"rightsizing\" animal-based experiments, with sample size estimates based on the fundamentals of statistical thinking: structured research questions, variation control and appropriate design of experiments. The result is a much-needed guide to planning animal-based experiments to ensure scientifically valid and reliable results. \u003c\/p\u003e\u003cp\u003eThis book offers: \u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eStep-by-step guidance in diverse methods for approximating and refining sample size\u003c\/li\u003e \u003cli\u003eDetailed treatment of research topics specific to animal-based research, including pilot, feasibility and proof-of-concept studies\u003c\/li\u003e \u003cli\u003eSample size approximation methods for different types of data - binary, continuous, ordinal, time to event - and different study types - description, comparison, nested designs, reference interval construction and dose-response studies\u003c\/li\u003e \u003cli\u003eNumerous worked examples, using real data from published papers, together with SAS and R code\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003e\u003ci\u003eA Guide to Sample Size for Animal-based Studies\u003c\/i\u003e is a must-have reference for preclinical and veterinary researchers, as well as ethical oversight committees and policymakers.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Penny S. Reynolds\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 111979997X\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781119799979\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Wiley-Blackwell\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 09\/12\/2023\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 288\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.49lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 11.00h x 8.50w x 0.61d\u003c\/p\u003e","brand":"Penny S. Reynolds","offers":[{"title":"Paperback","offer_id":44302200111359,"sku":"9781119799979","price":71.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_a099069b-441a-4bc3-9270-421dd15071ea.jpg?v=1695160100","url":"https:\/\/www.whiterainbookhouse.com\/products\/a-guide-to-sample-size-penny-s-reynolds-9781119799979","provider":"WR Book House","version":"1.0","type":"link"}