{"product_id":"a-practical-guide-to-rational-sun-hongmao-9780081000984","title":"A Practical Guide to Rational Drug Design","description":"\u003cp\u003eThis book is not going to be an exhaustive survey covering all aspects of rational drug design. Instead, it is going to provide critical know-how through real-world examples. Relevant case studies will be presented and analyzed to illustrate the following: how to optimize a lead compound whether one has high or low levels of structural information; how to derive hits from competitors' active compounds or from natural ligands of the targets; how to springboard from competitors' SAR knowledge in lead optimization; how to design a ligand to interfere with protein-protein interactions by correctly examining the PPI interface; how to circumvent IP blockage using data mining; how to construct and fully utilize a knowledge-based molecular descriptor system; how to build a reliable QSAR model by focusing on data quality and proper selection of molecular descriptors and statistical approaches. \u003ci\u003eA Practical Guide to Rational Drug Design\u003c\/i\u003e focuses on computational drug design, with only basic coverage of biology and chemistry issues, such as assay design, target validation and synthetic routes.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Sun Hongmao\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 0081000987\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9780081000984\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Woodhead Publishing\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 10\/12\/2015\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 292\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.30lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 8.90h x 6.10w x 0.70d","brand":"Sun Hongmao","offers":[{"title":"Hardcover","offer_id":47930620805375,"sku":"9780081000984","price":210.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_cae1a53d-0f62-43a7-8e4f-3f3273f78a9e.jpg?v=1766343106","url":"https:\/\/www.whiterainbookhouse.com\/products\/a-practical-guide-to-rational-sun-hongmao-9780081000984","provider":"WR Book House","version":"1.0","type":"link"}