{"product_id":"adhesion-gpcrs-simon-yona-9781441979124","title":"Adhesion-Gpcrs: Structure to Function","description":"Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand-receptor complex into numerous cellular responses. The importance of GPCRs is further reflected in the fact that they constitute the most common target for therapeutic drugs across a 2 wide range of human disorders. Phylogenetic analysis of GPCRs produced the GRAFS classification system, which subdivides GPCRs into five discrete families: glutamate, rhodopsin, adhesion, frizzled\/taste2 and secretin receptors. The adhesion-GPCR family 2 can be further subdivided into eight groups. The field of adhesion-GPCR biology has indeed become large enough to require a volume dedicated solely to this field. The contributors to this book have made a courageous effort to address the key concepts of adhesion-GPCR biology, including the evolution and biochemistry of adhesion-GPCRs; there are extensive discussions on the functional nature of these receptors during development, the immune response and tumourgenesis. Finally, there are chapters dedicated to adhesion-GPCR signalling, an area of intense investigation.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Simon Yona\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1441979123\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781441979124\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Springer\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 01\/11\/2011\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 199\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.30lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 10.50h x 7.20w x 0.50d","brand":"Simon Yona","offers":[{"title":"Hardcover","offer_id":47425262944511,"sku":"9781441979124","price":169.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_ac001960-cdd8-465e-a8ae-43c82390523e.jpg?v=1761538056","url":"https:\/\/www.whiterainbookhouse.com\/products\/adhesion-gpcrs-simon-yona-9781441979124","provider":"WR Book House","version":"1.0","type":"link"}