{"product_id":"advances-in-medicinal-chemistry-b-e-maryanoff-9780762300648","title":"Advances in Medicinal Chemistry: Volume 4","description":"Volume 4 of \u003ci\u003eAdvances in Medicinal Chemistry\u003c\/i\u003e is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol(R) (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e B. E. Maryanoff\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 0762300647\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9780762300648\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Elsevier Science\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 04\/01\/1999\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 321\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover","brand":"B. E. Maryanoff","offers":[{"title":"Hardcover","offer_id":48112962830591,"sku":"9780762300648","price":125.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_88055ac0-3b4e-4b9d-8b20-66305b85226a.jpg?v=1769612128","url":"https:\/\/www.whiterainbookhouse.com\/products\/advances-in-medicinal-chemistry-b-e-maryanoff-9780762300648","provider":"WR Book House","version":"1.0","type":"link"}