{"product_id":"anti-malaria-drugs-and-plasmodium-falciparum-eltayeb-ali-9783659357312","title":"Anti-malaria Drugs and Plasmodium falciparum Gametocytes Prevalence","description":"We monitored post-treatment Plasmodium falciparum among patients treated with chloroquine (CQ) and Fansidar (SP) in a village in eastern Sudan. Parasites were examined on day0, day7, day14 and day21 during the transmission season. A further sample was taken 2 months later (day80) at the start of the dry season. Asexual forms and gametocytes were detected by microscopy, and reverse transcriptase polymerase chain reaction (RT-PCR) was used to detect expression of gametocyte-specific proteins pfs25 and pfg377. Microscopic gametocytes increased significantly following CQ and SP treatment, reaching a maximum between days7 and14. When measured by RT-PCR, however, there was no significant difference in gametocyte rate between day0 and days7 or 14. RT-PCR gametocyte rates dropped dramatically by day80 post treatment but were still 33% and 8% in the CQ- and SP-treated groups at this time. Drug resistance alleles to CQ (pfcrt, and pfmdr1) and to SP (dhfr) were seen at a high frequency at the beginning of treatment and increased further through time following both drug treatments. Infections with drug-resistant parasites tended to have higher gametocyte prevalence than drug-sensitive infectio\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Eltayeb Ali\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3659357316\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783659357312\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e LAP Lambert Academic Publishing\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 03\/06\/2013\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 136\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.46lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.00h x 6.00w x 0.32d","brand":"Eltayeb Ali","offers":[{"title":"Paperback","offer_id":44073669394687,"sku":"9783659357312","price":63.72,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_56e54650-bb1a-4a19-94db-74fba5a22083.jpg?v=1685449200","url":"https:\/\/www.whiterainbookhouse.com\/products\/anti-malaria-drugs-and-plasmodium-falciparum-eltayeb-ali-9783659357312","provider":"WR Book House","version":"1.0","type":"link"}