{"product_id":"antibody-drug-conjugates-hovhannes-j-gukasyan-9783031893186","title":"Antibody Drug Conjugates: Design, Discovery, and Development","description":"\u003cp\u003eThis volume ​provides a comprehensive recapitulation of structure-activity relationship (SAR) from a mechanism of action point of view for this unique therapeutic modality, in a largely disease agnostic manner. From a disease biology and pharmacology perspective, the cellular target and drug-conjugate selection, considerations on liker -chemistry and -antibody ratio, and formulation science and technology, to get from bench to bedside (i.e. from a laboratory to the systemic circulation in a patient). The book also provides an understanding around target binding and drug\/\"payload\" release mechanisms. Furthermore, pharmacokinetic and safety pharmacological aspects from a regulatory and clinical perspective are discussed, along with current chemistry, manufacturing, controls guidance and emerging novel delivery devices or technologies.\u003c\/p\u003e  \u003cp\u003eThe key differentiation in \u003cem\u003eAntibody Drug Conjugates\u003c\/em\u003e is the clinical and development discussion, that offers pragmatic considerations in medical product development, IP, regulatory considerations, among others. Furthermore, we discuss the topic as a platform, in a disease agnostic manner.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Hovhannes J. Gukasyan\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3031893182\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783031893186\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Springer\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 02\/06\/2026\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 229\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover","brand":"Hovhannes J. Gukasyan","offers":[{"title":"Hardcover","offer_id":47579919089919,"sku":"9783031893186","price":139.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_836e94fe-defc-4e07-9efd-a8ee0a3516e7.jpg?v=1763877571","url":"https:\/\/www.whiterainbookhouse.com\/products\/antibody-drug-conjugates-hovhannes-j-gukasyan-9783031893186","provider":"WR Book House","version":"1.0","type":"link"}