{"product_id":"anticancer-agents-from-natural-products-gordon-m-cragg-9781439813829","title":"Anticancer Agents from Natural Products","description":"\u003cp\u003eThe approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, \u003cstrong\u003eAnticancer Agents from Natural Products, Second Edition\u003c\/strong\u003e covers the: \u003c\/p\u003e \u003cp\u003e\u003c\/p\u003e \u003cul\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eHistory of each covered drug-a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications\u003c\/li\u003e \u003cli\u003ePotential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery\u003c\/li\u003e \u003cli\u003eImportant biosynthetic approaches to \"unnatural\" natural products \u003c\/li\u003e \u003cp\u003e\u003c\/p\u003e\n\u003c\/ul\u003e \u003cp\u003e\u003c\/p\u003e \u003cp\u003e\u003cstrong\u003eAnticancer Agents from Natural Products, Second Edition\u003c\/strong\u003e discusses how complex target-oriented synthesis-enabled by historic advances in methodology-has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future. \u003c\/p\u003e \u003cp\u003e\u003c\/p\u003e \u003cp\u003e\u003cem\u003eExamples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.\u003c\/em\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Gordon M. Cragg\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1439813825\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781439813829\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e CRC Press\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 10\/10\/2011\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 784\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 3.44lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 10.00h x 7.00w x 1.63d","brand":"Gordon M. Cragg","offers":[{"title":"Hardcover","offer_id":48458305503487,"sku":"9781439813829","price":305.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_ab0b8c78-514e-47ea-bd6a-bdf916151062.jpg?v=1777403612","url":"https:\/\/www.whiterainbookhouse.com\/products\/anticancer-agents-from-natural-products-gordon-m-cragg-9781439813829","provider":"WR Book House","version":"1.0","type":"link"}