{"product_id":"application-of-modern-toxicology-approaches-national-academies-of-sciences-engineeri-9780309376662","title":"Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense","description":"\u003cp\u003eThe US Department of Defense (DOD) is faced with an overwhelming task in evaluating chemicals that could potentially pose a threat to its deployed personnel. There are over 84,000 registered chemicals, and testing them with traditional toxicity-testing methods is not feasible in terms of time or money. In recent years, there has been a concerted effort to develop new approaches to toxicity testing that incorporate advances in systems biology, toxicogenomics, bioinformatics, and computational toxicology. Given the advances, DOD asked the National Research Council to determine how DOD could use modern approaches for predicting chemical toxicity in its efforts to prevent debilitating, acute exposures to deployed personnel. This report provides an overall conceptual approach that DOD could use to develop a predictive toxicology system. \u003ci\u003eApplication of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense\u003c\/i\u003e reviews the current state of computational and high-throughput approaches for predicting acute toxicity and suggests methods for integrating data and predictions. This report concludes with lessons learned from current high-throughput screening programs and suggests some initial steps for DOD investment.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e National Academies of Sciences Engineeri,Division on Earth and Life Studies,Board on Life Sciences\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 0309376661\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9780309376662\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e National Academies Press\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 10\/01\/2015\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 134\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.10lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.90h x 7.00w x 0.50d","brand":"National Academies of Sciences Engineeri","offers":[{"title":"Paperback","offer_id":48447688442111,"sku":"9780309376662","price":58.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_585bcf18-da30-4063-a4df-92fb29ed706e.jpg?v=1777234141","url":"https:\/\/www.whiterainbookhouse.com\/products\/application-of-modern-toxicology-approaches-national-academies-of-sciences-engineeri-9780309376662","provider":"WR Book House","version":"1.0","type":"link"}