{"product_id":"bayesian-designs-for-phase-i-ii-ying-yuan-9781032242644","title":"Bayesian Designs for Phase I-II Clinical Trials","description":"\u003cp\u003eReliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose or schedule may lead to failure in later trials. At the same time, if promising preclinical results do not translate into a real treatment advance, it is important to determine this quickly and terminate the clinical evaluation process to avoid wasting resources. \u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eBayesian Designs for Phase I-II Clinical Trials\u003c\/strong\u003e describes how phase I-II designs can serve as a bridge or protective barrier between preclinical studies and large confirmatory clinical trials. It illustrates many of the severe drawbacks with conventional methods used for early-phase clinical trials and presents numerous Bayesian designs for human clinical trials of new experimental treatment regimes.\u003c\/p\u003e\u003cp\u003eWritten by research leaders from the University of Texas MD Anderson Cancer Center, this book shows how Bayesian designs for early-phase clinical trials can explore, refine, and optimize new experimental treatments. It emphasizes the importance of basing decisions on both efficacy and toxicity. \u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Ying Yuan, Hoang Q. Nguyen, Peter F. Thall\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1032242647\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781032242644\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e CRC Press\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 12\/13\/2021\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 324\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback","brand":"Ying Yuan","offers":[{"title":"Paperback","offer_id":43945692594431,"sku":"9781032242644","price":54.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/products\/img_262ccda8-76cb-48ac-b3d4-3428baabf26f.jpg?v=1681509408","url":"https:\/\/www.whiterainbookhouse.com\/products\/bayesian-designs-for-phase-i-ii-ying-yuan-9781032242644","provider":"WR Book House","version":"1.0","type":"link"}