{"product_id":"benign-and-pathological-chromosomal-imbalances-thomas-liehr-9780124046313","title":"Benign and Pathological Chromosomal Imbalances: Microscopic and Submicroscopic Copy Number Variations (Cnvs) in Genetics and Counseling","description":"\u003cp\u003e\u003ci\u003eBenign \u0026amp; Pathological Chromosomal Imbalances\u003c\/i\u003e systematically clarifies the disease implications of cytogenetically visible copy number variants (CG-CNV) using cytogenetic assessment of heterochromatic or euchromatic DNA variants. While variants of several megabasepair can be present in the human genome without clinical consequence, visually distinguishing these benign areas from disease implications does not always occur to practitioners accustomed to costly molecular profiling methods such as FISH, aCGH, and NGS. \u003c\/p\u003e \u003cp\u003eAs technology-driven approaches like FISH and aCGH have yet to achieve the promise of universal coverage or cost efficacy to sample investigated, deep chromosome analysis and molecular cytogenetics remains relevant for technology translation, study design, and therapeutic assessment.\u003c\/p\u003e \u003cp\u003eKnowledge of the rare but recurrent rearrangements unfamiliar to practitioners saves time and money for molecular cytogeneticists and genetics counselors, helping to distinguish benign from harmful CG-CNV. It also supports them in deciding which molecular cytogenetics tools to deploy. \u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Thomas Liehr\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 0124046312\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9780124046313\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Academic Press\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 09\/25\/2013\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 220\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.10lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.30h x 6.00w x 0.60d","brand":"Thomas Liehr","offers":[{"title":"Hardcover","offer_id":48587605639423,"sku":"9780124046313","price":99.95,"currency_code":"USD","in_stock":false}],"url":"https:\/\/www.whiterainbookhouse.com\/products\/benign-and-pathological-chromosomal-imbalances-thomas-liehr-9780124046313","provider":"WR Book House","version":"1.0","type":"link"}