{"product_id":"biomarkers-of-preeclampsia-pragati-sheel-mittal-9798378068463","title":"Biomarkers of Preeclampsia","description":"Preeclampsia is a multifaceted disorder related to pregnancy. In order to assess the predictive value of different biomarkers related to it; and finally proposing the best marker for routine use in clinical settings for its screening; this study has been undertaken.\u003cbr\u003eScreening, the deliberate examination of substantial segments of the population in search for disease at its earliest stages, is a logical extension of the role of preventive medicine and one that is becoming increasingly popular. Ideally a screening test should be inexpensive, easy to perform, readily interpretable and readily available to the entire population at risk. Also a screening test for the entire population must be acceptable to the population.\u003cbr\u003eOngoing research shows abundant evidence that the pathophysiological changes of Preeclampsia were present long before the clinical presentation of the disorder, which probably explains why all the management of Preeclampsia are only palliative till delivery. This indicates that for an effective therapy to be successful, the therapy has to be instituted before clinically evident disease.\u003cbr\u003eThe study can be concluded as follows: \u003cul\u003e\n\u003cli\u003eIn the present study the Urinary Calcium\/Creatinine Ratio in asymptomatic normotensive pregnant women in second trimester had been measured and followed them up to the delivery. The statistical analysis of the results showed that there lies a very significant relationship between low Urinary Calcium\/Creatinine Ratio and the development of Preeclampsia later in pregnancy.\u003c\/li\u003e\n\u003cli\u003eIn the present study the Serum levels of Calcium, Magnesium and Uric acid in preeclamptic women had been measured and compared those with normal pregnant women in third trimester. Based on the results of the present study and data available from literature, it is clear that in Preeclampsia, the Serum levels of Calcium and Magnesium were found lower than normal while Serum Uric acid levels were higher indicating the possible role of these biomarkers in the pathophysiological of Preeclampsia.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cul\u003e\u003cli\u003eWe have developed a predictive model for \u003cb\u003escreening Preeclampsia\u003c\/b\u003e and subgroups at \u003cb\u003e\u003ci\u003eincreased risk\u003c\/i\u003e\u003c\/b\u003e in which prior therapy might be indicated \u003cb\u003eto prevent maternal and perinatal morbidity and mortality\u003c\/b\u003e.\u003c\/li\u003e\u003c\/ul\u003eThus predictors of Preeclampsia with high sensitivity and moderate specificity will be useful initially in the conduct of clinical trials and perhaps eventually for therapy in future.\u003cbr\u003eSpot Urinary Calcium\/Creatinine Ratio is simple, cheap and easy to perform, noninvasive, specific and sensitive; which could also add up the diagnostic predictability of Preeclampsia. The role of Calcium\/ Creatinine Ratio appears to be significant \u0026amp; it may be used as additional marker for Preeclampsia in Antenatal care (ANC) profile. Therefore, we recommend that analysis of spot Urinary Calcium\/Creatinine Ratio may be an effective screening method for impending Preeclampsia and useful to identify population at greater risk. So, it could be included in \u003cb\u003eprimary prevention programs\u003c\/b\u003e. \u003cp\u003e\u003c\/p\u003eSerum Calcium, Magnesium and Uric acid levels should also be estimated as a part of \u003cb\u003eSecondary prevention programs\u003c\/b\u003e in diagnosed cases of Preeclampsia to prevent further complications.\u003cbr\u003eLaboratory facilities should be developed at Primary health centre level for Spot urine examination for above mentioned markers to prevent disease and its comorbidities.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Pragati Sheel Mittal,Shilpa Mittal\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9798378068463\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Independently Published\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 02\/18\/2023\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 110\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.26lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 8.00h x 5.00w x 0.23d","brand":"Pragati Sheel Mittal","offers":[{"title":"Paperback","offer_id":47419697234175,"sku":"9798378068463","price":10.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_ea3e618c-fd22-4560-b280-2e1cdd643760.jpg?v=1761513269","url":"https:\/\/www.whiterainbookhouse.com\/products\/biomarkers-of-preeclampsia-pragati-sheel-mittal-9798378068463","provider":"WR Book House","version":"1.0","type":"link"}