{"product_id":"cancer-genome-and-tumor-microenvironment-andrei-thomas-tikhonenko-9781461425243","title":"Cancer Genome and Tumor Microenvironment","description":"\u003cp\u003eOncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late '80s-early '90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are \"soft-wired\", i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these non-cell-autonomous changes might be one of the primary reasons such mutations are preserved in late-stage tumors.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Andrei Thomas-Tikhonenko\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1461425247\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781461425243\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Springer\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 03\/07\/2012\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 480\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.56lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.21h x 6.14w x 1.03d","brand":"Andrei Thomas-Tikhonenko","offers":[{"title":"Paperback","offer_id":47930805813503,"sku":"9781461425243","price":219.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_0decd495-91a2-4d8a-a729-d08f680557a5.jpg?v=1766344394","url":"https:\/\/www.whiterainbookhouse.com\/products\/cancer-genome-and-tumor-microenvironment-andrei-thomas-tikhonenko-9781461425243","provider":"WR Book House","version":"1.0","type":"link"}