{"product_id":"cardiac-safety-of-noncardiac-drugs-joel-morganroth-9781588295156","title":"Cardiac Safety of Noncardiac Drugs: Practical Guidelines for Clinical Research and Drug Development","description":"It is generally easy to define the efficacy of a new the- peutic agent. However, what is even more difficult and more challenging yet more important is to define its safety when administered to millions of patients with multi-faceted d- eases, co-morbidities, sensitivities and concomitant medi- tions. The commonest cause of new drug discontinuations, cause for disapproval from marketing and removal from the market after approval is a drug's effect on cardiac repolari- tion which is essentially identified by increasing the duration of the QTc interval duration on the standard 12-lead elect- cardiogram (ECG). Cardiac Safety of Noncardiac Drugs: Practical Guide- Joel Morganroth, MD lines for Clinical Research and Drug Development is designed to present the current preclinical, clinical, and re- latory principles to assess the cardiac safety of new drugs based primarily on their effects on the ECG. Practical gu- ance to define cardiac safety at all stages of clinical research and drug development are featured and discussed by inter- tionally recognized experts with academic, industrial, and regulatory experience. Each chapter contains the best ava- able evidence, the author's personal opinions, areas of c- troversy, and future trends. Although some of the areas are highly specialized, this book has been designed for a broad audience ranging from medical and graduate students to cli- cal nurses, clinical trial coordinators, safety officers, data managers, statisticians, regulatory authorities, clinicians, and Ihor Gussak, MD, PhD scientists.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Joel Morganroth\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 158829515X\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781588295156\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Humana\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 11\/04\/2004\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 362\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 2.07lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 10.44h x 7.18w x 1.00d","brand":"Joel Morganroth","offers":[{"title":"Hardcover","offer_id":47452736880895,"sku":"9781588295156","price":169.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_bfa20c25-551e-49a4-9f80-44f0b08e9dac.jpg?v=1761930206","url":"https:\/\/www.whiterainbookhouse.com\/products\/cardiac-safety-of-noncardiac-drugs-joel-morganroth-9781588295156","provider":"WR Book House","version":"1.0","type":"link"}