{"product_id":"challenges-in-biological-cryo-electron-royal-society-of-chemistry-9781839164255","title":"Challenges in Biological Cryo Electron Microscopy: Faraday Discussion 240","description":"\u003cp\u003eDevelopments in cryo-electron microscopy are creating new opportunities within structural biology and there is currently great interest in developing cryo-EM as a core tool for atomic level structural biology. Many structural techniques can give atomic or near atomic level information, but lack the ability to study proteins within a near-native environment, for example within a cellular compartment. Cryo-EM provides this opportunity, but despite the recent massive improvements in single particle cryo-EM, obtaining sub-2ﾅ structural information is still a major challenge. Cryo-electron microscopy has undergone significant developments in microscope design, camera technology and data processing regimes, but there are significant challenges that remain and opportunities to explore, many of which must be tackled by the community as a whole, rather than by individual groups. For example, sample preparation is central to electron microscopy and is currently a significant bottleneck in many experiments, and there are significant problems with ensuring the integrity of the field in terms of dealing with inherently low signal-to-noise images.\u003c\/p\u003e \u003cp\u003eThis volume brings together leading researchers from the UK and the international cryo-electron microscopy community to discuss current developments and new challenges in the field.\u003c\/p\u003e \u003cp\u003eIn this volume the topics covered include: \u003c\/p\u003e \u003cul\u003e \u003cli\u003eSample preparation in single particle cryo-EM\u003c\/li\u003e \u003cli\u003ePushing the limits in single particle cryo-EM\u003c\/li\u003e \u003cli\u003eTomographic analysis, CLEM\u003c\/li\u003e \u003cli\u003eMap\/model validation and machine learning in EM\u003c\/li\u003e\n\u003c\/ul\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Royal Society of Chemistry\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1839164255\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781839164255\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Royal Society of Chemistry\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 12\/12\/2022\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 338\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.45lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.30h x 6.30w x 1.00d","brand":"Royal Society of Chemistry","offers":[{"title":"Hardcover","offer_id":44069546000639,"sku":"9781839164255","price":235.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_ac97b474-2c7e-445f-95ae-534f91798582.jpg?v=1685425294","url":"https:\/\/www.whiterainbookhouse.com\/products\/challenges-in-biological-cryo-electron-royal-society-of-chemistry-9781839164255","provider":"WR Book House","version":"1.0","type":"link"}