{"product_id":"chemical-linkers-in-antibody-drug-conjugates-floris-van-delft-9781839162633","title":"Chemical Linkers in Antibody-Drug Conjugates (Adcs)","description":"\u003cp\u003eThe covalent conjugation of potent cytotoxic agents to monoclonal antibodies, known as antibody-drug conjugates (ADCs) is a powerful approach in the field of targeted treatment of cancer. Clearly, both monoclonal antibody and cytotoxic payload are crucial elements in determining the clinical value of an ADC and have receive ample attention. However, the structural element connecting the two -the chemical linker- also plays an essential role in mode-of-action, efficacy, pharmacokinetics and safety profile of an ADC, but is often underappreciated in considerations of ADC design.\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eChemical Linkers in Antibody-Drug Conjugates\u003c\/strong\u003e\u003cem\u003e \u003c\/em\u003eaims to shine a detailed light on the various key attributes of chemical linkers in ADCs, for drug-to-antibody ratio, for stability, for release mechanism of payload, for pharmacokinetics, for stability determination, and for efficacy and safety. Ideal for postgraduate students and active researchers in drug discovery and development, this book provides a comprehensive description of linkers used in ADCs (clinical and late preclinical), insight into key quality attributes of linkers for ADCs, and aids the reader in understanding the role of linker chemistry and designing new ADCs.\u003c\/p\u003e\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Floris Van Delft\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1839162635\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781839162633\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Royal Society of Chemistry\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 12\/22\/2021\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 460\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.90lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.20h x 6.30w x 1.20d","brand":"Floris Van Delft","offers":[{"title":"Hardcover","offer_id":43990439297279,"sku":"9781839162633","price":235.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_5f6b3376-a5d9-4208-8c14-086ddccf5425.jpg?v=1683304677","url":"https:\/\/www.whiterainbookhouse.com\/products\/chemical-linkers-in-antibody-drug-conjugates-floris-van-delft-9781839162633","provider":"WR Book House","version":"1.0","type":"link"}