{"product_id":"chemokine-receptors-in-cancer-amy-m-fulton-9781603272667","title":"Chemokine Receptors in Cancer","description":"\u003cp\u003eChemokines are a superfamily of low molecular weight cytokines that were initially described based on their ability to induce the directed migration of leukocytes to sites of inflammation or injury. In humans, there are approximately 45 chemokines that bind to 19 G-protein-coupled receptors. In addition to mediating cellular migration, chemokines have now been shown to affect many cellular functions including survival, adhesion, invasion, proliferation, and to regulate circulating chemokine levels. Although chemokine receptors were first described on leukocytes, it is now appreciated that chemokine receptors are also expressed by many other cells including endothelial and epithelial cells.\u003c\/p\u003e \u003cp\u003eSince the first description of chemokine receptors on malignant cells in 2001, an extensive literature has developed describing the expression and function of chemokine receptors in many malignancies. These studies support the initial hypothesis that malignant cells use chemokine receptors to migrate to distant sites of ligand expression and that expression of certain receptors is associated with a poor prognosis. It has also become apparent that malignancies of different tissues may use a diverse profile of chemokine receptors and that the same receptor may mediate metastasis to different sites in tumors of different histological origins. Receptor function may also maintain survival and expansion of the primary tumor.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Amy M. Fulton\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1603272666\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781603272667\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Humana\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 05\/27\/2009\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 172\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.97lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.21h x 6.14w x 0.50d\u003cbr\u003e\u003cbr\u003e\u003cb\u003eReview Citation(s): \u003c\/b\u003e\u003cbr\u003e\u003ci\u003eScitech Book News\u003c\/i\u003e 12\/01\/2009 pg. 113","brand":"Amy M. Fulton","offers":[{"title":"Hardcover","offer_id":48518959792383,"sku":"9781603272667","price":169.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_2cefe21c-a46b-46e1-80d6-9781df2b47dc.jpg?v=1778736302","url":"https:\/\/www.whiterainbookhouse.com\/products\/chemokine-receptors-in-cancer-amy-m-fulton-9781603272667","provider":"WR Book House","version":"1.0","type":"link"}