{"product_id":"chemokine-roles-in-immunoregulation-and-philip-m-murphy-9783662054055","title":"Chemokine Roles in Immunoregulation and Disease","description":"In autumn 2002, the Ernst Schering Research Foundation Workshop sponsored the 45th in its series of conferences devoted to emerging areas in basic and applied biomedical research. These conferences bring together a critical mass of top scientists working in an impor- tant area in an intimate setting that fosters the free exchange of knowledge and ideas. In this spirit, Workshop 45 assembled leaders in the field of chemokines - hemotactic cytokines that coordinate leukocyte trafficking - amid the scenic vineyards and wineries of Napa Valley, to discuss the latest concepts of how these molecules regulate the immune response and disease. Chemokines were se- lected as a conference topic because they have revitalized the study of leukocyte trafficking and are widely considered to be potential new targets for drug development, in diseases ranging from acute in- flammation and autoimmunity to HIV and cancer. Discovered in the 1980s, the chemokine superfamily currently has 43 human members, making it the largest subset of cytokines. Mem- bers are defined by conserved sequences and a common three-di- mensional fold, and can be divided into two major functional groups - homeostatic and inflammatory - depending on whether they are produced constitutively, and thereby control basal lymphocyte traf- ficking, or whether they must be induced, for example by pathogens or injury, and thereby control deployment of effector leukocytes in emergencies.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Philip M. Murphy\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3662054051\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783662054055\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Springer\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 10\/03\/2013\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 160\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.49lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 8.27h x 5.83w x 0.38d","brand":"Philip M. Murphy","offers":[{"title":"Paperback","offer_id":47930949304575,"sku":"9783662054055","price":169.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_115faf3c-4583-4f8d-92c9-9a4b0e20fdb7.jpg?v=1766345406","url":"https:\/\/www.whiterainbookhouse.com\/products\/chemokine-roles-in-immunoregulation-and-philip-m-murphy-9783662054055","provider":"WR Book House","version":"1.0","type":"link"}