{"product_id":"comprehensive-reanalysis-of-genomic-storm-deepak-tanwar-9783656858454","title":"Comprehensive Reanalysis of Genomic Storm (Transcriptomic) Data, Integrating Clinical Varibles and Utilizing New and Old Approaches","description":"Bachelor Thesis from the year 2014 in the subject Computer Science - Bioinformatics, grade: 165\/200 (A+), language: English, abstract: Aim: I sought to determine trauma-specific transcriptomic signatures for septic sub-cohorts. Methods: In retrospective large-scale data analysis, I applied (old and new methods), including lagged correlation between transcripts and clinical subtype counts (by integrating over 800 samples from trauma patients). Results: Focussing on novel pathways and correlation methods we revealed (persistently down-regulated) ribosomal genes and changed time profiles of metabolic enzyme precursors \/transcripts. Candidates associated to insulin signalling, including HK3, hinted towards \"metabolic syndrome\". Correlation analysis yielded robust results for LCN2 and LTF (r\u0026gt;0.9), but only moderate associations to subtype counts (e.g. top-performing r (Eosinophil, IL5RA)\u0026gt;0.6). Discussion: Gene Centred Normalisation Reduces Ambiguity and Improves Interpretation.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Deepak Tanwar\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3656858454\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783656858454\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Grin Verlag\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 01\/20\/2015\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 56\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.19lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 8.27h x 5.83w x 0.13d","brand":"Deepak Tanwar","offers":[{"title":"Paperback","offer_id":48217635487999,"sku":"9783656858454","price":48.9,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_20b29b15-2fa7-4fee-ba7d-177e91b43834.jpg?v=1771998464","url":"https:\/\/www.whiterainbookhouse.com\/products\/comprehensive-reanalysis-of-genomic-storm-deepak-tanwar-9783656858454","provider":"WR Book House","version":"1.0","type":"link"}