{"product_id":"computational-glioscience-maurizio-de-pittza-9783030008154","title":"Computational Glioscience","description":"Part 1. Introduction.- A Neuron-Glial perspective for computational neuroscience.- Part 2. Calcium dynamics.- Data-driven modelling of the inositol trisphosphate receptor and its role in calcium induced calcium release.- Intracellular calcium dynamics: biophysical and simplified models.- Modeling of stochastic Ca2+ signals.- G protein-coupled receptor-mediated astrocytic Ca2+ signaling in astrocytes.- Emergence of regular and complex calcium oscillations by inositol 1,4,5-trisphosphate signaling in astrocytes.- Astrocyte networks and intercellular calcium propagation.- Part 3. Tripartite Synapse and regulation of network activity.- Tripartite synapses and regulation of synaptic plasticity.- Purinergic signaling at tripartite synapses.- Gliotransmitter exocytosis and its consequences on synaptic transmission.- Computational models of pathophysiological glial activation in CNS disorders.- Part 4. Homeostasis and Metabolic coupling.- The role of astrocytes in neurotransmitter uptake and brain metabolism.- Glutamate uptake.- Astrocytic ion dynamics: Implications for potassium buffering and liquid flow.- Constraint-Based Modeling of Metabolic Interactions in and between Astrocytes and Neurons.- Part 5. Computational Tools to Analyze and Model Astrocyte Experiments.- Computational models of astrocytes and astrocyte-neuron interactions: Characterization, reproducibility, and future perspectives.- GECIquant: semi-automated detection and quantification of astrocyte intracellular Ca2+ signals monitored with GCaMP6f.- Modeling neuron-glia interactions with the Brian 2.0 simulator.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Maurizio de Pittà\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3030008150\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783030008154\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Springer\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 01\/31\/2019\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 505\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.99lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.21h x 6.14w x 1.13d","brand":"Maurizio de Pittà","offers":[{"title":"Hardcover","offer_id":46807029350655,"sku":"9783030008154","price":199.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_7acfd38f-7e32-40cc-ae7d-60f7c45677af.jpg?v=1745378356","url":"https:\/\/www.whiterainbookhouse.com\/products\/computational-glioscience-maurizio-de-pittza-9783030008154","provider":"WR Book House","version":"1.0","type":"link"}