{"product_id":"cytochrome-p450-zhengyin-yan-9781071615416","title":"Cytochrome P450: In Vitro Methods and Protocols","description":"\u003cb\u003e1. Cytochrome P450: In Vitro Methods and Protocols\u003c\/b\u003e\u003cp\u003e Zhengyin Yan and Gary W. Caldwell\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e2. Characteristics of Major Drug Metabolizing Cytochrome P450 Enzymes\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Kevin Johnson, Dian Su, and Donglu Zhang\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e3. Quantitative Determination of Cytochrome P450 Using LC\/MS\/MS\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Ryan H. Takahashi, Brahim Achour, and Bhagwat Prasad\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e4. Spectral Quantitation of Total Cytochrome P450 in Microsomes Using a Single-Beam Spectrophotometer\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e David M. Stresser\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e5. Cytochrome P450 Enzyme Kinetics: Km and Vmax Determinations Using Metabolite Formation and Substrate Depletion Methods\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Jing Wang\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e6. Cytochrome P450 Inhibition Assay Using Human Liver Microsomes\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Jia Jia\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e7. Evaluation of Time-Dependent Cytochrome P450 Inhibition Using the Area Under the Curve Shift Method\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Julie Huang\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e8. Assessing Cytochrome P450 Time Dependent Inhibition (IC50 Shift Assay) Using Both Diluted and Non-Diluted Methods\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Yu Wang, Lili Xie, and Jing Ni\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e9. Cytochrome P450 Gene Regulation: Reporter Assays to Assess Pregnane X Receptor (PXR, NR1I2) Activation\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Marija Pinne and Judy L. Raucy\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e10. Cytochrome P450 Gene Regulation: Reporter Assays to Assess Aryl Hydrocarbon Receptor (HLHE76, AhR) Activation and Antagonism\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Marija Pinne and Judy L. Raucy\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e11. Cytochrome P450 Gene Regulation: Reporter Assays to Assess Direct and Indirect Activation of Constitutive Androstane Receptor (CAR, NR1I3)\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Marija Pinne and Judy L. Raucy\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e12. Determination of In Vitro Cytochrome P450 Induction Potential Using Cryopreserved Human Hepatocytes\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Susan Wong\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e13. Assessing Cytochrome P450 3A (CYP3A) Induction and Suppression Using Primary Human Hepatocyte Spheroids\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Jing Wang and Eugene Chen\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e14. Cytochrome P450-Mediated Metabolic Stability Assay in Liver Microsomes\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Pasquale Carione\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e15. Assessment of Cytochrome P450 Metabolic Clearance Using Hepatocyte Suspension\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Jingwei Cai and Hadil Shalan\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e16. Cytochrome P450 Knock-Out Assay with Non-Selective Inhibitors\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Pasquale Carione and Zhengyin Yan\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e17. Differentiation of Cytochrome P450-Mediated from Non-CYP-Mediated Metabolism: Aldehyde Oxidase and Xanthine Oxidoreductase\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e Kirk D. Kozminski and Michael A. Zientek\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\u003cb\u003e18. In Vitro\u003ci\u003e \u003c\/i\u003eReaction Phenotyping of Cytochrome P450 Enzymes\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e \u0026amp;...\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Zhengyin Yan\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1071615416\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781071615416\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Humana\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 07\/10\/2021\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 379\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.90lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 10.20h x 7.70w x 0.90d\u003c\/p\u003e","brand":"Zhengyin Yan","offers":[{"title":"Hardcover","offer_id":44127439061247,"sku":"9781071615416","price":199.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_91101284-c18b-4408-9abc-6dd0ef34f769.jpg?v=1687453490","url":"https:\/\/www.whiterainbookhouse.com\/products\/cytochrome-p450-zhengyin-yan-9781071615416","provider":"WR Book House","version":"1.0","type":"link"}