{"product_id":"cytochrome-p450-zhengyin-yan-9781071615447","title":"Cytochrome P450: In Vitro Methods and Protocols","description":"This collection explores detailed experimental protocols necessary for setting up a variety of \u003ci\u003ein vitro\u003c\/i\u003e cytochrome P450 (CYP) assays that are vital in selecting drug candidates in a drug discovery pipeline. Major factors affecting drug metabolism include CYP expression levels, kinetic parameters for individual CYP enzymes, CYP inhibition and induction, time-dependent inhibition (TDI), CYP stability, non-CYP stability, UDP-glucuronosyltransferases (UGT) stability, excretion mechanisms, and drug-drug interactions (DDI), all addressed in this volume. Written for the \u003ci\u003eMethods in Pharmacology and Toxicology\u003c\/i\u003e series, chapters include helpful background information on the \u003ci\u003ein vitro\u003c\/i\u003e assay, a list of all the materials, reagents, and equipment necessary to carry out the assay, a step-by-step protocol, notes containing common and unexpected experimental problems in the assay, as well as references containing important supplementary reading. \u003cbr\u003eAuthoritative and practical, \u003ci\u003eCytochrome P450: In Vitro Methods and Protocols\u003c\/i\u003e serves as a key guide for researchers in the area of discovery and development of new medicines.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Zhengyin Yan\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1071615440\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781071615447\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Humana\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 07\/10\/2022\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 379\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.49lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 10.00h x 7.00w x 0.81d","brand":"Zhengyin Yan","offers":[{"title":"Paperback","offer_id":44123262746879,"sku":"9781071615447","price":129.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_4d78fa23-c6bd-4e95-82a5-03e90cf43db7.jpg?v=1687429876","url":"https:\/\/www.whiterainbookhouse.com\/products\/cytochrome-p450-zhengyin-yan-9781071615447","provider":"WR Book House","version":"1.0","type":"link"}