{"product_id":"cytochromes-p450-patrick-m-dansette-9783036502564","title":"Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0","description":"\u003cp\u003eThis book, \u003cstrong\u003e\"Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity\"\u003c\/strong\u003e, \u003cstrong\u003e \u003c\/strong\u003epresents five papers on human cytochrome P450 (CYP) and P450 reductase, three reviews on the role of CYPs in humans and their use as biomarkers, six papers on CYPs in microorganisms, and one study on CYP in insects.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eThe first paper reports the in silico modeling of human CYP3A4 access channels. The second uses structural methods to explain the mechanism-based inactivation of CYP3A4 by mibefradil, 6,7-dihydroxy-bergamottin, and azamulin. The third article compares electron transfer in CYP2C9 and CYP2C19 using structural and biochemical methods, and the fourth uses kinetic methods to study electron transfer to CYP2C8 allelic mutants. The fifth article characterizes electron transfer between the reductase and CYP using in silico and in vitro methods, focusing on the conformations of the reductase.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eThen, two reviews describe clinical implications in cardiology and oncology and the role of fatty acid metabolism in cardiology and skin diseases. The second review is on the potential use of circulating extracellular vesicles as biomarkers.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eFive papers analyze the CYPomes of diverse microorganisms: the Bacillus genus, Mycobacteria, the fungi Tremellomycetes, Cyanobacteria, and Streptomyces. The sixth focuses on a specific Mycobacterium CYP, CYP128, and its importance in M. tuberculosis.\u003c\/p\u003e\u003cp\u003e \u003c\/p\u003e\u003cp\u003eThe subject of the last paper is CYP in \u003cem\u003eSogatella furcifera\u003c\/em\u003e, a plant pest, and its resistance to the insecticide sulfoxaflor\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Patrick M. Dansette\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3036502564\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783036502564\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Mdpi AG\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 06\/30\/2021\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 286\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.80lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.61h x 6.69w x 0.94d","brand":"Patrick M. Dansette","offers":[{"title":"Hardcover","offer_id":44598688383231,"sku":"9783036502564","price":72.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_1fa162fe-6922-432b-839a-a57b2392f582.jpg?v=1702383880","url":"https:\/\/www.whiterainbookhouse.com\/products\/cytochromes-p450-patrick-m-dansette-9783036502564","provider":"WR Book House","version":"1.0","type":"link"}