{"product_id":"development-of-isatin-as-cns-kiran-gangarapu-9783954892792","title":"Development of Isatin as CNS Agents: Anticonvulsant activity","description":"The present study was aimed at synthesizing isatin-5-sulphonamide derivatives are prepared by chlorosulphonation of isatin to prepare isatin-5-sulphonic acid chloride and it is subjected to reaction with different amines or anilines to form respective sulphonamide derivatives. The new compounds were characterized based on spectral (FT-IR, NMR and Mass) analysis. All the test compounds showed CNS depression while studying the gross behavioral changes. All the test compounds exhibited reduction in locomotor activity. Compound IIIf (R = p-toluidino) showed more reduction in the locomotor activity among all the test compounds. Compounds IIId, IIIc, IIIb, IIIa were next in the order of reduction of locomotor activity. The compounds were evaluated for anticonvulsant activity against maximum electric shock induced and Pentylenetetrazol (PTZ) induced seizures in mice using phenytoin as a standard.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Kiran Gangarapu\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3954892790\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783954892792\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Anchor Academic Publishing\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 06\/12\/2014\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 56\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.19lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 8.27h x 5.83w x 0.13d","brand":"Kiran Gangarapu","offers":[{"title":"Paperback","offer_id":47611887550719,"sku":"9783954892792","price":63.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_59de0a40-35b7-4a38-8d9e-401c73c59a0b.jpg?v=1764516738","url":"https:\/\/www.whiterainbookhouse.com\/products\/development-of-isatin-as-cns-kiran-gangarapu-9783954892792","provider":"WR Book House","version":"1.0","type":"link"}