{"product_id":"diagnosis-of-hirschsprungs-disease-raja-jouini-9786208624392","title":"Diagnosis of Hirschsprung's disease","description":"Hirschsprung's disease (HD) is a rare congenital disorder defined by the absence of ganglion cells (GCs) in a segment of the digestive tract. Its diagnosis in Tunisia relies solely on histopathological study with hemathein-eosin. Currently, several studies are being carried out on biomarkers of MH, notably on the anti-calretinin antibody. The aim of our work was to evaluate the diagnostic performance of the anti-calretinin antibody in the context of suspected HD. This was a retrospective study including 69 patients with MH. An immunohistochemical study with anti-calretinin antibody was performed. In MPA biopsies, CGs were labeled in 2 biopsies, while interstitial nerve fibers were labeled in 3 biopsies. The sensitivity, specificity, positive predictive value and negative predictive value of the anti-calretinin antibody were 93%, 100%, 100% and 70% respectively.The use of an immunohistochemical study with anti-calretinin antibody in the absence of GC is a reasonable alternative in view of the serious therapeutic implications of HD.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Raja Jouini,Imen Helal,Sarra Yacoub\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 6208624398\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9786208624392\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Our Knowledge Publishing\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 02\/10\/2025\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 68\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.23lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.00h x 6.00w x 0.16d","brand":"Raja Jouini","offers":[{"title":"Paperback","offer_id":48446501978367,"sku":"9786208624392","price":63.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_c32f2a6c-094f-47b2-a3a8-f4ee26ce98d8.jpg?v=1777225053","url":"https:\/\/www.whiterainbookhouse.com\/products\/diagnosis-of-hirschsprungs-disease-raja-jouini-9786208624392","provider":"WR Book House","version":"1.0","type":"link"}