{"product_id":"dna-recombination-stephen-kowalczykowski-9781621820093","title":"DNA Recombination","description":"Homologous recombination involves the precise exchange of similar or identical nucleic acid sequences between two DNA molecules. This process directs the repair of many DNA lesions in somatic cells and generates genetic variation in sperm and egg cells during meiosis. It is a nearly universal biological process that is conserved from phage to humans. \u003cp\u003e\u003c\/p\u003eWritten and edited by experts in the field, this collection from \u003cem\u003eCold Spring Harbor Perspectives in Biology \u003c\/em\u003ecovers all aspects of recombinational DNA repair, meiotic recombination, and the regulation of these processes. The contributors examine the dozens of proteins that are involved in recombinational repair and the various pathways in which they are employed (e.g., gene conversion or break-induced replication). They also discuss how these proteins and pathways are strictly regulated to avoid genomic instability, which can lead to diseases such as cancer, and how they are coordinated with other nuclear processes (e.g., transcription and DNA replication). \u003cp\u003e\u003c\/p\u003eMeiotic recombination, the characteristics that distinguish it from recombinational repair, and effects of its dysregulation (e.g., aneuploidy) are also covered in depth. This volume is an indispensable reference for biochemists, molecular biologists, and cell biologists who want to understand how DNA recombination maintains genomic integrity in individual organisms and across generations.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Stephen Kowalczykowski\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1621820092\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781621820093\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Cold Spring Harbor Laboratory Press\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 09\/30\/2015\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 549\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 3.10lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 10.00h x 7.00w x 1.20d","brand":"Stephen Kowalczykowski","offers":[{"title":"Hardcover","offer_id":43939303293183,"sku":"9781621820093","price":135.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/products\/img_5423a631-9630-438f-ae2e-a4acdada6199.jpg?v=1681440704","url":"https:\/\/www.whiterainbookhouse.com\/products\/dna-recombination-stephen-kowalczykowski-9781621820093","provider":"WR Book House","version":"1.0","type":"link"}