{"product_id":"dna-replicons-next-generation-vaccines-maximilian-gabler-9783836495554","title":"DNA Replicons - Next-generation Vaccines against Allergy","description":"In this study, DNA vaccines based on alphaviral replicases (DNA replicons) were evaluated with respect to their protective and therapeutic capacity for treatment of type I allergy. DNA replicons display specific danger signals and offer an excellent safety profile based on apoptotic elimination of transfected host cells thereby preventing undesirable long-term expression of the transfected gene. Using the model allergen beta-Galactosidase in a protective approach, the results showed that a replicase-based DNA vaccine can induce a comparable immune response at a more than 1000-fold lower dose than a conventional DNA vaccine. DNA replicon doses as low as 10 ng significantly prevented from IgE induction by subcutaneous protein sensitization. Furthermore, in a therapeutic approach with the same construct, DNA replicons balanced an ongoing allergic response. These data were confirmed with a DNA replicon encoding the clinically relevant timothy grass pollen allergen Phl p 5. In addition, lung pathology could be prevented by pre-vaccination with DNA replicons as measured by the magnitude of eosinophilia, goblet cell hyperplasia, IL-5 production and proliferation of endothelial cells.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Maximilian Gabler\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3836495554\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783836495554\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e VDM Verlag Dr. Mueller E.K.\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 04\/08\/2008\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 132\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.41lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.00h x 6.00w x 0.28d","brand":"Maximilian Gabler","offers":[{"title":"Paperback","offer_id":48066392064255,"sku":"9783836495554","price":63.72,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_4dbc55a7-4584-4337-9b43-2fe447dc95a6.jpg?v=1768678241","url":"https:\/\/www.whiterainbookhouse.com\/products\/dna-replicons-next-generation-vaccines-maximilian-gabler-9783836495554","provider":"WR Book House","version":"1.0","type":"link"}