{"product_id":"dose-finding-by-the-continual-ying-kuen-cheung-9781420091519","title":"Dose Finding by the Continual Reassessment Method","description":"\u003cp\u003eAs clinicians begin to realize the important role of dose-finding in the drug development process, there is an increasing openness to \"novel\" methods proposed in the past two decades. In particular, the Continual Reassessment Method (CRM) and its variations have drawn much attention in the medical community, though it has yet to become a commonplace tool. To overcome the status quo in phase I clinical trials, statisticians must be able to design trials using the CRM in a timely and reproducible manner. \u003c\/p\u003e\u003cp\u003eA self-contained theoretical framework of the CRM for researchers and graduate students who set out to learn and do research in the CRM and dose-finding methods in general, \u003cstrong\u003eDose Finding by the Continual Reassessment Method\u003c\/strong\u003e features: \u003c\/p\u003e\u003cul\u003e \u003cp\u003e \u003c\/p\u003e \u003cli\u003eReal clinical trial examples that illustrate the methods and techniques throughout the book\u003c\/li\u003e \u003cli\u003eDetailed calibration techniques that enable biostatisticians to design a CRM in timely manner\u003c\/li\u003e \u003cli\u003eLimitations of the CRM are outlined to aid in correct use of method\u003c\/li\u003e \u003c\/ul\u003e\u003cp\u003eThis book supplies practical, efficient dose-finding methods based on cutting edge statistical research. More than just a cookbook, it provides full, unified coverage of the CRM in addition to step-by-step guidelines to automation and parameterization of the methods used on a regular basis. A detailed exposition of the calibration of the CRM for applied statisticians working with dose-finding in phase I trials, the book focuses on the R package 'dfcrm' for the CRM and its major variants.\u003c\/p\u003e\u003cp\u003eThe author recognizes clinicians' skepticism of model-based designs, and addresses their concerns that the time, professional, and computational resources necessary for accurate model-based designs can be major bottlenecks to the widespread use of appropriate dose-finding methods in phase I practice. The theoretically- and empirically-based methods in \u003cstrong\u003eDose Finding by the Continual Reassessment Method\u003c\/strong\u003e will lessen the statistician's burden and encourage the continuing development and implementation of model-based dose-finding methods. \u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Ying Kuen Cheung\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1420091514\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781420091519\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e CRC Press\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 06\/01\/2010\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 205\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.95lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.30h x 6.20w x 0.60d\u003cbr\u003e\u003cbr\u003e\u003cb\u003eReview Citation(s): \u003c\/b\u003e\u003cbr\u003e\u003ci\u003eReference and Research Bk News\u003c\/i\u003e 06\/01\/2011 pg. 275","brand":"Ying Kuen Cheung","offers":[{"title":"Hardcover","offer_id":48088207327487,"sku":"9781420091519","price":210.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_a42f6889-fe26-4451-a65c-3c2e6079daef.jpg?v=1769103649","url":"https:\/\/www.whiterainbookhouse.com\/products\/dose-finding-by-the-continual-ying-kuen-cheung-9781420091519","provider":"WR Book House","version":"1.0","type":"link"}