{"product_id":"drosophila-immunity-handbook-hannah-westlake-9782889156467","title":"Drosophila Immunity Handbook","description":"\u003cb\u003eExplores the genetics of \u003ci\u003eDrosophila\u003c\/i\u003e, or fruit flies, to further the study of immunity.\u003c\/b\u003e \u003cp\u003e\u003c\/p\u003e Animals possess efficient mechanisms for detecting and neutralizing infection. The application of \u003ci\u003eDrosophila\u003c\/i\u003e genetics, or the genetics of fruit flies, to the study of these mechanisms has generated insights into insect immunity and uncovered general principles of animal host defense. Although it is difficult to summarize the sheer number of studies published on Drosophila immunity in recent years, the \u003ci\u003eDrosophila Immunity Handbook\u003c\/i\u003e aims to provide an overview of recent research trends, challenges, and discoveries in immunity through the lens of Drosophila. This overview introduces scientists to the sophisticated fly immune system, highlights exciting recent findings in the field, and pushes new horizons of research by contextualizing existing research and discovering exciting avenues to explore. \u003cp\u003e\u003c\/p\u003e These studies have shown that Drosophila have multiple defense \"modules\" that can be deployed in a coordinated response against distinct pathogens, using physical barriers such as epithelia and chitin, production of reactive oxygen species, antimicrobial factors, blood clotting, the melanization reaction, and complex cellular responses. Metabolic reprogramming also fuels the immune system and effectively combats pathogens, as do symbiont-mediated immunity, disease tolerance mechanisms, and behavioral immunity. The research presented here reveals broader roles of the immune system beyond infection, notably in disease pathologies such as neurodegeneration or cancer. This remarkable animal model has ultimately given us a better understanding of the multiple roles of the immune system at the organismal level.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Hannah Westlake, Mark A. Hanson, Bruno Lemaitre\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 288915646X\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9782889156467\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Epfl Press\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 12\/26\/2024\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 200\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback","brand":"Hannah Westlake","offers":[{"title":"Paperback","offer_id":46545909612799,"sku":"9782889156467","price":49.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_110570b2-ceff-41f4-9180-4e10bd3eb1ae.jpg?v=1738183669","url":"https:\/\/www.whiterainbookhouse.com\/products\/drosophila-immunity-handbook-hannah-westlake-9782889156467","provider":"WR Book House","version":"1.0","type":"link"}