{"product_id":"drosophila-melanogaster-biosensors-of-malinda-wilson-9783639130621","title":"Drosophila Melanogaster - Biosensors of Atmospheric Oxidative Stress","description":"Studies of Drosophila melanogaster have led to molecular insights concerning biomolecular mechanisms of biology and disease including development, differentiation, cancer and aging. Wild-type Drosophila, unlike vertebrate mammals, selectively retains gamma-tocopherol over alpha- tocopherol. Urate-deficient Drosophila compared to wild-type had similar levels of glutathione but only 50% of the ascorbate levels. Dietary supplementation with ascorbate dramatically increased its level while chemically-defined diets led to rapid depletion of ascorbate in both strains. It is concluded that Drosophila do not synthesize ascorbate, and in this respect are similar to humans. Wild-type and urate-deficient Drosophila were continuously exposed to ozone. Exposure of Drosophila to 2 ppm ozone\/24hrs\/day unmasked a marked sensitivity phenotype of urate-deficient Drosophila. Studies revealed that ascorbate supplementation decreased ozone-induced toxicity in Drosophila. Collectively, these data reveal the usefulness of Drosophila as a model organism for studying micronutrient antioxidants and their interrelationship with ozone-induced toxicity.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Malinda Wilson\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3639130626\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783639130621\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e VDM Verlag\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 03\/12\/2009\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 112\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.39lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.00h x 6.00w x 0.27d","brand":"Malinda Wilson","offers":[{"title":"Paperback","offer_id":48454052282623,"sku":"9783639130621","price":52.92,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_9b36da19-12f7-4d6c-bfc6-5a6bc6663775.jpg?v=1777303898","url":"https:\/\/www.whiterainbookhouse.com\/products\/drosophila-melanogaster-biosensors-of-malinda-wilson-9783639130621","provider":"WR Book House","version":"1.0","type":"link"}