{"product_id":"electrostatic-considerations-in-mitosis-l-john-gagliardi-9781440173783","title":"Electrostatic Considerations in Mitosis: Integrating Physics and Cell Biology in Mitosis","description":"Identifying the motive force is central to explaining chromosome motions during mitosis. Presently, there is no consensus on what it is. The author has proposed a minimal assumptions model for the dynamics of post-attachment chromosome motions based on nanoscale electrostatics. Given the electrical properties of tubulin and the dynamic instability of microtubules, it is possible to account for prometaphase post-attachment, metaphase, and anaphase chromosome motions within a comprehensive model. The model addresses all of the following in a unified manner: \u003cul\u003e \u003cli\u003eEfficiency of aster and spindle assembly and the motive force for the motion of asters and forming half-spindles. \u003c\/li\u003e\n\u003cli\u003eChromatid pair attachment. \u003c\/li\u003e\n\u003cli\u003eMotion of monovalently attached chromatid pairs. \u003c\/li\u003e\n\u003cli\u003eMotion of bivalently attached chromatid pairs and chromosome congression. \u003c\/li\u003e\n\u003cli\u003eMetaphase chromatid pair oscillations. \u003c\/li\u003e\n\u003cli\u003eChromatid separation and anaphase-A chromosome motion. \u003c\/li\u003e\n\u003cli\u003eAnaphase-B pole separation. \u003c\/li\u003e\n\u003cli\u003eAn ab-initio calculation of the maximum tension force exerted by a microtubule during mitosis that falls within the experimental range. \u003c\/li\u003e\n\u003cli\u003ePoleward force generation of chromosomes at poles with associated microtubule flux.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e L. John Gagliardi\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1440173788\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781440173783\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e iUniverse\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 10\/29\/2009\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 124\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.39lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.00h x 6.00w x 0.26d","brand":"L. John Gagliardi","offers":[{"title":"Paperback","offer_id":43935017828607,"sku":"9781440173783","price":13.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/products\/img_22436eca-3667-4201-aeaa-8f53efc212e1.jpg?v=1681417373","url":"https:\/\/www.whiterainbookhouse.com\/products\/electrostatic-considerations-in-mitosis-l-john-gagliardi-9781440173783","provider":"WR Book House","version":"1.0","type":"link"}