{"product_id":"enzyme-inhibition-in-drug-discovery-chuang-lu-9780470281741","title":"Enzyme Inhibition in Drug Discovery and Development","description":"The science and applied approaches of enzyme inhibition in drug discovery and development \u003cp\u003eOffering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, \u003ci\u003eEnzyme Inhibition in Drug Discovery and Development\u003c\/i\u003e examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development.\u003c\/p\u003e \u003cp\u003eWith chapters written by over fifty leading experts in their fields, \u003ci\u003eEnzyme Inhibition in Drug Discovery and Development\u003c\/i\u003e fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the \"good\" inhibitions--desirable pharmacological effects--and \"bad\" inhibitions--drug-drug interactions and toxicity. The book discusses: \u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003eThe drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eThe manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug-drug interactions\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eThe inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathway\u003c\/p\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThrough this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Chuang Lu\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 047028174X\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9780470281741\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Wiley\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 01\/01\/2010\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 868\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 2.80lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.30h x 6.30w x 1.70d\u003cbr\u003e\u003cbr\u003e\u003cb\u003eReview Citation(s): \u003c\/b\u003e\u003cbr\u003e\u003ci\u003eScitech Book News\u003c\/i\u003e 03\/01\/2010 pg. 61","brand":"Chuang Lu","offers":[{"title":"Hardcover","offer_id":44119727145215,"sku":"9780470281741","price":251.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_2041a05a-6ee8-45af-b1dd-f484837a064b.jpg?v=1687410646","url":"https:\/\/www.whiterainbookhouse.com\/products\/enzyme-inhibition-in-drug-discovery-chuang-lu-9780470281741","provider":"WR Book House","version":"1.0","type":"link"}