{"product_id":"epilepsy-jeffrey-l-noebels-9781621821502","title":"Epilepsy: The Biology of a Spectrum Disorder","description":"Epilepsy is due to abnormal signaling of neurons in the brain that can cause seizures. It is a common condition, affecting at least 3% of individuals at some point during their life. The seizures are difficult to predict and, in a significant fraction of patients, refractory to current medical interventions. \u003cp\u003e\u003c\/p\u003eWritten and edited by experts in the field, this collection from \u003cem\u003eCold Spring Harbor Perspectives in Medicine\u003c\/em\u003e includes contributions covering all aspects of epilepsy, its causes, pathophysiology, clinical characteristics, comorbidities, and treatment. Contributors discuss the genetic, developmental, and environmental triggers of recurrent seizures; molecular changes (e.g., epigenetic modifications) that are associated with epileptogenesis; and the aberrant ion channels and neuronal networks involved. Clinical aspects of the disease (diagnosis, classification, and treatments) are reviewed, as are common comorbidities (e.g., depression and cognitive disorders). Recent advances in drug development and surgical techniques aimed at reducing the morbidity and mortality of patients with epilepsy are also described. \u003cp\u003e\u003c\/p\u003eThe authors highlight current challenges in the field of epilepsy, with the goal of assisting others in formulating relevant research questions. This volume is therefore a vital reference not only for scientists and clinicians currently working in the field, but for all neuroscientists seeking to explore new research directions.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Jeffrey L. Noebels\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1621821501\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781621821502\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Cold Spring Harbor Laboratory Press\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 12\/15\/2015\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 459\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 2.45lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 10.00h x 7.00w x 0.90d","brand":"Jeffrey L. Noebels","offers":[{"title":"Paperback","offer_id":48447958941951,"sku":"9781621821502","price":79.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_19e646a8-9a79-4c50-89dc-2c8690fa3e30.jpg?v=1777235961","url":"https:\/\/www.whiterainbookhouse.com\/products\/epilepsy-jeffrey-l-noebels-9781621821502","provider":"WR Book House","version":"1.0","type":"link"}