{"product_id":"g-protein-signaling-alan-v-smrcka-9781588291370","title":"G Protein Signaling: Methods and Protocols","description":"Since the initial discovery of the G protein-coupled receptor system that regulates cyclicAMP production, the G protein field has rapidly expanded. Cell surface receptors that couple to heterotrimeric G proteins, the G prote- coupled receptors (GPCRs), number in the hundreds and bind to a wide div- sity of ligands including, biogenic amines (e. g., adrenaline), lipid derivatives (e. g., lysophosphatidic acid), peptides (e. g., opioid peptides), proteins (e. g., thyroid-stimulating hormone), and odorants to name a few. The GPCR system is found throughout biology in such simple organisms as yeast and in such more complex organisms as Dictyostelium discoideum (slime mold), Caen- habditis elegans (nematode worm), and of course in humans. GPCRs and their associated G protein systems are the subject of intense academic research and because of their involvement in a human biology and disease, the pharmac- tical industry has large research initiatives dedicated to the study of GPCRs. By some estimates, more than 50% of the pharmaceuticals on the market are targeted at GPCRs. The G protein\/G protein-coupled receptor system consists of a receptor (GPCR), a heterotrimeric G protein consisting of ?, ?, and ? subunits, and an effector. G protein effector molecules, such as enzymes or ion channels, respond to acti- tion by the G protein to generate second messengers or changes in membrane potential that lead to alterations in cell physiology.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Alan V. Smrcka\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1588291375\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781588291370\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Humana\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 09\/15\/2003\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 250\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.38lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.18h x 6.22w x 0.95d","brand":"Alan V. Smrcka","offers":[{"title":"Hardcover","offer_id":47424435519743,"sku":"9781588291370","price":109.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_d2cd0466-f551-42cb-a41a-2293bef6d998.jpg?v=1761530209","url":"https:\/\/www.whiterainbookhouse.com\/products\/g-protein-signaling-alan-v-smrcka-9781588291370","provider":"WR Book House","version":"1.0","type":"link"}