{"product_id":"handbook-of-molecular-genetic-techniques-for-wim-e-crusio-9780444502391","title":"Handbook of Molecular-Genetic Techniques for Brain and Behavior Research: Volume 13","description":"The book gives a broad overview of recombinant DNA techniques for the behavioral neuroscientist, with illustrative examples of applications. Species covered include rodents (mainly mice), \u003ci\u003eDrosophila melanogaster, Caenorhabditis elegans\u003c\/i\u003e and \u003ci\u003eDanio rerio.\u003c\/i\u003e Experimental techniques required to characterize the behavioral phenotypes of mutant animals is provided. Several aspects of novel molecular-genetic techniques are overviewed and possible research strategies are explained. The sections of the book start with general descriptions of techniques followed by illustrative examples. \u003cp\u003e\u003c\/p\u003eIt is divided into six sections. Section 1, bioinformatics and genomics research. Section 2, top-down strategies, where the researcher starts with the phenotype and then analyzes the associated genes; bottom-up strategies, where the physiological chain leading to a phenotype is analyzed starting from the gene product. Section 3, transgenic approaches in rodents including overexpressing foreign genes and gene-targeting; systemic manipulation approaches directly targeting the central nervous system and methods used with invertebrates. Section 4, methods used to evaluate relevant behavioral phenotypes, including learning and aggression. Section 5, examples on molecular brain research in man. Section 6, ethical aspects of research in this field.\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Wim E. Crusio\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 0444502394\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9780444502391\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Elsevier Science\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 10\/18\/1999\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 962\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 5.42lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 10.52h x 7.85w x 1.69d","brand":"Wim E. Crusio","offers":[{"title":"Hardcover","offer_id":48112903979263,"sku":"9780444502391","price":230.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_f5e126e6-854b-474d-a787-4c055dd61b06.jpg?v=1769611725","url":"https:\/\/www.whiterainbookhouse.com\/products\/handbook-of-molecular-genetic-techniques-for-wim-e-crusio-9780444502391","provider":"WR Book House","version":"1.0","type":"link"}