{"product_id":"hedgehog-signaling-xiaochun-li-9781071617007","title":"Hedgehog Signaling: Methods and Protocols","description":"This detailed book explores the technical breakthroughs with biophysical and cell biological approaches that have advanced the study of molecular mechanisms underlying the generation and transduction of the hedgehog (HH) signal, indicating the important role of sterols in this pathway. Within its pages, the volume examines techniques involving several key protein components in this pathway, including HH, the signaling ligand; Dispatched, a HH secretion regulator; Patched, the receptor of HH; Smoothened, the signal transducer used to transduce the HH signal across the plasma membrane; and GLI, the transcription factor to turn on HH target genes. Written in the highly successful \u003ci\u003eMethods in Molecular Biology\u003c\/i\u003e series format, chapters feature introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. \u003cbr\u003eAuthoritative and practical, \u003ci\u003eHedgehog Signaling: Methods and Protocols\u003c\/i\u003e provides researchers in clinical and basic science with a fresh and reliable reference for analyzing HH signal transduction through cell biological, biochemical, and biophysical approaches.\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Xiaochun Li\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1071617001\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781071617007\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Humana\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 09\/27\/2021\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 244\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.40lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 10.20h x 8.00w x 0.70d","brand":"Xiaochun Li","offers":[{"title":"Hardcover","offer_id":48087523295487,"sku":"9781071617007","price":199.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_cb7f7654-120b-49a5-8732-c9b42c7d56d7.jpg?v=1769100548","url":"https:\/\/www.whiterainbookhouse.com\/products\/hedgehog-signaling-xiaochun-li-9781071617007","provider":"WR Book House","version":"1.0","type":"link"}