{"product_id":"heteroaromatic-lipoxin-a4-analogues-colm-duffy-9783642438929","title":"Heteroaromatic Lipoxin A4 Analogues: Synthesis and Biological Evaluation","description":"\u003cp\u003eIn this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation. \u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Colm Duffy\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 364243892X\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783642438929\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Springer\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 02\/22\/2014\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 130\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.48lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.00h x 6.00w x 0.50d","brand":"Colm Duffy","offers":[{"title":"Paperback","offer_id":44138677764351,"sku":"9783642438929","price":109.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_4d270c54-5528-4e86-b447-cecf7d4489fb.jpg?v=1687900951","url":"https:\/\/www.whiterainbookhouse.com\/products\/heteroaromatic-lipoxin-a4-analogues-colm-duffy-9783642438929","provider":"WR Book House","version":"1.0","type":"link"}