{"product_id":"heterogeneity-in-statistical-genetics-derek-gordon-9783030611200","title":"Heterogeneity in Statistical Genetics: How to Assess, Address, and Account for Mixtures in Association Studies","description":"\u003cp\u003eHeterogeneity, or mixtures, are ubiquitous in genetics. Even for data as simple as mono-genic diseases, populations are a mixture of affected and unaffected individuals. Still, most statistical genetic association analyses, designed to map genes for diseases and other genetic traits, ignore this phenomenon.\u003c\/p\u003e \u003cp\u003eIn this book, we document methods that incorporate heterogeneity into the design and analysis of genetic and genomic association data. Among the key qualities of our developed statistics is that they include mixture parameters as part of the statistic, a unique component for tests of association. A critical feature of this work is the inclusion of at least one heterogeneity parameter when performing statistical power and sample size calculations for tests of genetic association.\u003c\/p\u003e We anticipate that this book will be useful to researchers who want to estimate heterogeneity in their data, develop or apply genetic association statistics where heterogeneity exists, and accurately evaluate statistical power and sample size for genetic association through the application of robust experimental design.\u003cp\u003e\u003c\/p\u003e\u003cbr\u003e\u003cp\u003e\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Derek Gordon, Stephen J. Finch, Wonkuk Kim\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3030611205\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783030611200\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Springer\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 12\/17\/2020\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 352\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.54lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.21h x 6.14w x 0.88d","brand":"Derek Gordon","offers":[{"title":"Hardcover","offer_id":44073536389375,"sku":"9783030611200","price":129.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_a85d91fa-dd55-42c7-8b7c-725c518d5b31.jpg?v=1685448402","url":"https:\/\/www.whiterainbookhouse.com\/products\/heterogeneity-in-statistical-genetics-derek-gordon-9783030611200","provider":"WR Book House","version":"1.0","type":"link"}