{"product_id":"human-drug-metabolism-michael-d-coleman-9781119458562","title":"Human Drug Metabolism","description":"\u003cp\u003e\u003cb\u003eProvides a timely update to a key textbook on human drug metabolism\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eThe third edition of this comprehensive book covers basic concepts of teaching drug metabolism, starting from extreme clinical consequences to systems and mechanisms and toxicity. It provides an invaluable introduction to the core areas of pharmacology and examines recent progress and advances in this fast moving field and its clinical impact.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eHuman Drug Metabolism, 3rd Edition\u003c\/i\u003e begins by covering basic concepts such as clearance and bioavailability, and looks at the evolution of biotransformation, and how drugs fit into this carefully managed biological environment. More information on how cytochrome P450s function and how they are modulated at the sub-cellular level is offered in this new edition. The book also introduces helpful concepts for those struggling with the relationship of pharmacology to physiology, as well as the inhibition of biotransformational activity. Recent advances in knowledge of a number of other metabolizing systems are covered, including glucuronidation and sulphation, along with the main drug transporters. Also, themes from the last edition are developed in an attempt to chart the progress of personalized medicine from concepts towards practical inclusion in routine therapeutics. The last chapter focuses on our understanding of how and why drugs injure us, both in predictable and unpredictable ways. Appendix A highlights some practical approaches employed in both drug metabolism research and drug discovery, whilst Appendix B outlines the metabolism of some drugs of abuse. Appendix C advises on formal examination preparation and Appendix D lists some substrates, inducers and inhibitors of the major human cytochrome P450s.\u003c\/p\u003e \u003cul\u003e \u003cli\u003eFully updated to reflect advances in the scientific field of drug metabolism and its clinical impact\u003c\/li\u003e \u003cli\u003eReflects refinements in the author's teaching method, particularly with respect to helping students understand biological systems and how they operate\u003c\/li\u003e \u003cli\u003eIllustrates the growing relationship between drug metabolism and personalized medicine\u003c\/li\u003e \u003cli\u003eIncludes recent developments in drug discovery, genomics, and stem cell technologies\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eHuman Drug Metabolism, 3rd Edition\u003c\/i\u003e is an excellent book for advanced undergraduate and graduate students in molecular biology, biochemistry, pharmacology, pharmacy, and toxicology. It will also appeal to professionals interested in an introduction to this field, or who want to learn more about these bench-to-bedside topics to apply it to their practice.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Michael D. Coleman\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1119458560\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781119458562\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Wiley-Blackwell\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 02\/19\/2020\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 688\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 2.15lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.00h x 6.00w x 0.90d","brand":"Michael D. Coleman","offers":[{"title":"Paperback","offer_id":43924153434367,"sku":"9781119458562","price":94.95,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/products\/img_037c5521-3ba7-4128-8cf1-8dd787b9a389.jpg?v=1681068782","url":"https:\/\/www.whiterainbookhouse.com\/products\/human-drug-metabolism-michael-d-coleman-9781119458562","provider":"WR Book House","version":"1.0","type":"link"}