{"product_id":"immunological-investigation-of-autoimmune-bullous-ameni-jerbi-9786208187873","title":"Immunological investigation of autoimmune bullous dermatoses","description":"Autoimmune bullous dermatoses (ABD) are specific autoimmune diseases of the skin and mucous membranes. They are characterized by the presence of autoantibodies (auto-Ab) directed against skin and mucous membrane adhesion molecules, leading to altered function of their antigenic targets, resulting in clinical bullae and\/or erosions. Depending on the site of cleavage, a distinction is made between intra-epidermal DBAI, characterized by auto-Ac directed against the structural proteins of the desmosomes that hold the keratinocytes of the epidermis together; and sub-epidermal DBAI, characterized by the presence of auto-Ac directed against the components of the dermo-epidermal junction (DEJ).The diagnosis of DBAI is based on clinical, histopathological and immunological evidence (detection of circulating or tissue-deposited auto-Ac). Direct immunofluorescence (DIF) is an immunological technique performed on cryosections of peri-lesional biopsies, based on the detection of Ac deposits and\/or complement fractions using specific fluorescein-conjugated Ac.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Ameni Jerbi\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 6208187877\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9786208187873\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Our Knowledge Publishing\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 10\/16\/2024\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 52\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.20lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.00h x 6.00w x 0.12d","brand":"Ameni Jerbi","offers":[{"title":"Paperback","offer_id":48446485430527,"sku":"9786208187873","price":48.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_740434ab-e1fb-41cd-a449-e4d0c7d2aabe.jpg?v=1777224952","url":"https:\/\/www.whiterainbookhouse.com\/products\/immunological-investigation-of-autoimmune-bullous-ameni-jerbi-9786208187873","provider":"WR Book House","version":"1.0","type":"link"}