{"product_id":"inhaled-medicines-stavros-kassinos-9780128149744","title":"Inhaled Medicines: Optimizing Development Through Integration of in Silico, in Vitro and in Vivo Approaches","description":"\u003cp\u003eInhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes.\u003c\/p\u003e\u003ci\u003e \u003c\/i\u003e\u003cp\u003eInhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches explores the current state of the art with respect to inhalation drug delivery, technologies available to assess product performance, and novel in silico methods now available to link in vitro product performance to clinical performance. Recent developments in the latter field, especially the prospect of integration of three-dimensional Computational Fluid Particle Methods (3D-CFPD) with physiologically based pharmacokinetic (PBPK models), unlocks the potential for in silico population studies that can help inform and optimize treatment and product development strategies. In this highly multidisciplinary field, where progress occurs at the intersection of several disciplines of engineering and science, this work aims to integrate current knowledge and understanding and to articulate a clear vision for future developments.\u003c\/p\u003e\u003ci\u003e \u003c\/i\u003e\u003cp\u003e \u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Stavros Kassinos\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 0128149744\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9780128149744\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Academic Press\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 01\/22\/2021\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 438\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.95lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.10h x 7.50w x 0.90d","brand":"Stavros Kassinos","offers":[{"title":"Paperback","offer_id":48991622791423,"sku":"9780128149744","price":195.0,"currency_code":"USD","in_stock":false}],"url":"https:\/\/www.whiterainbookhouse.com\/products\/inhaled-medicines-stavros-kassinos-9780128149744","provider":"WR Book House","version":"1.0","type":"link"}