{"product_id":"inhibition-of-angiogenesis-by-potential-elisabeth-klenke-9783639036305","title":"Inhibition of Angiogenesis by Potential Chemopreventive Agents","description":"A new human in vitro anti-angiogenesis assay was established and applied to identify novel angiopreventive agents. Subsequently, two chemopreventive compounds, xanthohumol (XN) from Humulus lupu-lus L. (hop) and sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables (Brassicaceae), were selected for detailed in-vestigation of their angiopreventive potential and mechanisms invol-ved in the inhibition of angiogenesis. Representative targets included effects at the transcriptional levels of pro-angiogenic factors, anti-gelatinolytic and anti-endothelial activity. In vivo, XN was shown to exhibit a strong anti-tumour potency on human breast cancer xeno-grafts mediated by the inhibition of tumour-induced angiogenesis. These findings strongly suggest that XN and SFN represent attractive chemopreventive lead structures possessing a remarkable potential to prevent tumour development.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Elisabeth Klenke\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3639036301\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783639036305\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e VDM Verlag Dr. Mueller E.K.\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 06\/04\/2008\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 132\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.41lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.00h x 6.00w x 0.28d","brand":"Elisabeth Klenke","offers":[{"title":"Paperback","offer_id":48113837408511,"sku":"9783639036305","price":63.72,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_afe93c7f-53f5-46c5-bb76-2dbe54d8dc31.jpg?v=1769617504","url":"https:\/\/www.whiterainbookhouse.com\/products\/inhibition-of-angiogenesis-by-potential-elisabeth-klenke-9783639036305","provider":"WR Book House","version":"1.0","type":"link"}