{"product_id":"inhibitors-of-cyclin-dependent-kinases-as-paul-j-smith-9780849337741","title":"Inhibitors of Cyclin-Dependent Kinases as Anti-Tumor Agents","description":"\u003cp\u003eOne of the few books to cover all aspects of cyclin-dependent kinases (CDKs), \u003cb\u003eInhibitors of Cyclin-dependent Kinases as Anti-tumor Agents\u003c\/b\u003e provides an overview of CDKs as molecular and functional entities, their involvement in different disease processes, and their potential for pharmacological modulation. With contributions from the top international researchers in the field, the book takes a contemporary approach to study the importance of rational drug design and knowledge-based therapeutics in relation to CDKs.\u003c\/p\u003e\u003cp\u003eThe first two sections of the book discuss the integration of cell cycle control pathways, opportunities for targeting, targets of inhibitors, and the evaluation of CDK inhibitors, exploring topics such as the \u003ci\u003ein vivo \u003c\/i\u003efunction of CDKs in normal homeostasisand tumor development and the structural biology of CDKs. The third section examines the design, development, and chemistry of small molecule CDK inhibitors, with discussions ranging from the early-stage discovery of new chemical entities with a capacity to inhibit CDKs to late-stage compounds in clinical development. The final section assesses the current status of CDK inhibitors in clinical trials, the therapeutic deployment challenges of small molecule inhibitors, and the future development of CDK inhibitors as anticancer agents. \u003c\/p\u003e\u003cp\u003eThe field of drug development is at a critical point in terms of understanding the availability, advantages, and drawbacks of CDKs as therapeutic targets for small molecules. Providing the most up-to-date, in-depth coverage available in a single volume, \u003cb\u003eInhibitors of Cyclin-dependent Kinases as Anti-tumor Agents\u003c\/b\u003e surveys the success of the agents developed thus far, the possibility of new routes to more selective inhibitors, and the growing appreciation of critical, therapeutic issues.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Paul J. Smith\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 0849337747\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9780849337741\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e CRC Press\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 10\/01\/2006\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 448\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Hardcover\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.77lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.28h x 6.50w x 1.17d\u003cbr\u003e\u003cbr\u003e\u003cb\u003eReview Citation(s): \u003c\/b\u003e\u003cbr\u003e\u003ci\u003eScitech Book News\u003c\/i\u003e 03\/01\/2007 pg. 67","brand":"Paul J. Smith","offers":[{"title":"Hardcover","offer_id":48065213169919,"sku":"9780849337741","price":280.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_61e3e9c3-e2c4-482a-b8ef-4cce86fe90c7.jpg?v=1768673724","url":"https:\/\/www.whiterainbookhouse.com\/products\/inhibitors-of-cyclin-dependent-kinases-as-paul-j-smith-9780849337741","provider":"WR Book House","version":"1.0","type":"link"}