{"product_id":"interleukin-27-marek-jankowski-9783319396620","title":"Interleukin-27: Biological Properties and Clinical Application","description":"\u003cp\u003eThis volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike.\u003c\/p\u003e\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Marek Jankowski,Tomasz Wandtke\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3319396625\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783319396620\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Springer\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 05\/23\/2016\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 86\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.32lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.21h x 6.14w x 0.19d","brand":"Marek Jankowski","offers":[{"title":"Paperback","offer_id":47930929414399,"sku":"9783319396620","price":54.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_72aff112-2288-4dbb-8122-da1323177468.jpg?v=1766345268","url":"https:\/\/www.whiterainbookhouse.com\/products\/interleukin-27-marek-jankowski-9783319396620","provider":"WR Book House","version":"1.0","type":"link"}