{"product_id":"kinesin-protocols-isabelle-vernos-9781617371783","title":"Kinesin Protocols","description":"By the end of the 1980s only two microtubule-dependent motors, the plus end-directed kinesin and the minus end-directed cytoplasmic dynein, had been identified. At the time, these two motors seemed almost sufficient to explain directional motility events on polar microtubule tracks in the cell. No- theless, shortly after, the tip of the iceberg began to emerge with the identi- cation of proteins containing in their sequences a domain found in kinesin. This domain, called the \"motor domain,\" conferred on these proteins the essential property of moving on microtubules, using the energy derived from ATP hydro- sis. Since then, the identification of new proteins belonging to the kinesin superfamily of microtubule-dependent motors has gone at such a pace that nowadays more than 200 entries with motor domain sequences are deposited in the database. Kinesin family members are found in all eukaryotic org- isms tested. They present a wide range of domain organizations with a motor domain located at different positions in the molecule. Their motility prop- ties are also variable in directionality, velocity, and such other characteristics as bundling activity and processivity. Finally, and most important, they p- ticipate in a multitude of cellular functions. Our understanding of many cel- lar events, such as mitotic spindle assembly and neuronal transport, to cite only two, has progressed substantially in the last few years thanks to the id- tification of these motors.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Isabelle Vernos\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1617371785\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781617371783\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Humana\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 11\/10\/2010\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 258\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.89lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.00h x 6.00w x 0.61d","brand":"Isabelle Vernos","offers":[{"title":"Paperback","offer_id":47424445251839,"sku":"9781617371783","price":109.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_7f865c31-aeab-46f0-aec1-cb4418cb0a50.jpg?v=1761530269","url":"https:\/\/www.whiterainbookhouse.com\/products\/kinesin-protocols-isabelle-vernos-9781617371783","provider":"WR Book House","version":"1.0","type":"link"}