{"product_id":"know-your-poison-no-4-vijay-vasudev-pillay-9798711313724","title":"Know your Poison No. 4: IV Propofol: Toxic Riddle for the Toxic Detective: An Indian Society of Toxicology Initiative","description":"Toximonic of \"Falls on All IV = 4\" for Easy RecallProp-O-fol = pronounced as \"Prop 'O' Fall\" -Prop means to keep from falling or slipping by providing a support under or against-Fall is a 4-letter word, so propofol causes rapid fall in all vitals-\"IV\" means 4 as roman number-IV stands for Intra Venous, as propofol is injected as intravenous anesthetic. Prop-O-fol = causes Prop 'O' Fall: Toximonic of IV- Falls for Easy Recall: - 1)Fall in GCS (coma inducer)- thus the victim is knocked down, can't stand on all 4 limbs2)Fall in Intracranial pressure (ICP): helpful in Head injury \u0026amp; acute Brain Stroke3)Fall in Memory: Propofol is known as milk of amnesia by anesthetics 4)Fall in seizure rates recurrence during status epilepticus Overdose of IV- Propofol causes iatrogenic complications: -Fall in Breath rate (bradypnea) can cause apnea \u0026amp; decreased response to PaCO2 \u0026amp; PaO2 -\u0026gt; have to provide controlled ventilation if using boluses.-Fall in Blood Pressure (causes vasodilation and negative inotropy -\u0026gt; hypotension)-Fall in renal function: decrease renal blood flow and GFR from hypotension-Fall in muscle power by Rhabdomyolysis due to uncoupling of oxidative phosphorylation in mitochondrial ETC (electronic transport chain)-Fall in Pulse rate of Heart (bradyarrhythmia)-Fall in pancreatic function due to excess load of fatty acids in propofol infusion on prolonged use, causing pancreatitis Fall is a IV- 4-letter word: All 4's for easy recall: - 4- major indications of propofol use in allopathy:1)Induction + maintenance of General Anaesthesia2)Procedural Sedation for bronchoscopy, Upper gastrointestinal endoscopy, colonoscopy, sigmoidoscopy (Procedure done in posing on All 4's) 3)Status Epilepticus \u0026amp; Eclampsia, may provide some cerebral protection4)Status Asthmaticus: bronchodilator properties may be useful in treating bronchospasmsIV- 4- Nursing tips: Do's \u0026amp; Don'ts for propofol injection: -SHAKE WELL BEFORE USE-infuse undiluted; if there is a need to dilute prior to administration, use only dextrose 5%. -Do not dilute to a concentration\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Vijay Vasudev Pillay\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9798711313724\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Independently Published\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 02\/19\/2021\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 52\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.18lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.02h x 5.98w x 0.11d","brand":"Vijay Vasudev Pillay","offers":[{"title":"Paperback","offer_id":48137115926783,"sku":"9798711313724","price":5.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_b1b7c504-6718-4b4a-b181-fbdc7e7920fe.jpg?v=1770166648","url":"https:\/\/www.whiterainbookhouse.com\/products\/know-your-poison-no-4-vijay-vasudev-pillay-9798711313724","provider":"WR Book House","version":"1.0","type":"link"}