{"product_id":"lipid-metabolism-in-the-healthy-ger-j-van-der-vusse-9781461365594","title":"Lipid Metabolism in the Healthy and Disease Heart","description":"The discovery of the second-messenger functions of on serine and threonine residues. Although there is inositol 1,4,5-trisphosphate (Ins(1,4,5)P 3) and 1,2-dia- general agreement that PKC plays an important role in cylglycerol (DAG), the products of receptor-stimulated the initiation and\/or modulation of receptor-linked re- phosphatidylinositol 4,5-bisphosphate (PtdIns( 4,5)P ) 2 sponses, the precise nature or molecular details of this hydrolysis, marked a turning point in the studies on the involvement remain elusive. There are several sugges- mechanisms of mediation of functional hormone and tions of possible functions of PKC, including involve- neurotransmitter responses. The historical background ment in modulation of ionconductance, regulation of of this discovery and the extensive bibliography of the receptor interaction with components of (other) signal 2 enormously expanding knowledge in this field was re- transduction pathways, modulation of Ca + sensitivity cently presented by Rana and Hokin [1], the latter of contractile proteins and gene expression [6]. author who first observed the 'phosphoinositide' effect The receptors involved in the activation of the adeny- 35 years ago. It was, however, the Ca2+ gating hypothe- late cyclase and PtdIns cascade pathways have one com- sis proposed by Michell [2] on basis of a survey of mon feature. They are present in the plasmamembrane observations on the phosphoinositide turnover in a as complexes with GTP binding proteins (G-proteins).\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Ger J. Van Der Vusse\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 1461365597\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9781461365594\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Springer\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 10\/24\/2012\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 213\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 1.13lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 11.00h x 8.25w x 0.47d","brand":"Ger J. Van Der Vusse","offers":[{"title":"Paperback","offer_id":47930801258751,"sku":"9781461365594","price":169.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_2b453635-ba63-42ed-9b99-9ea223f13e0c.jpg?v=1766344366","url":"https:\/\/www.whiterainbookhouse.com\/products\/lipid-metabolism-in-the-healthy-ger-j-van-der-vusse-9781461365594","provider":"WR Book House","version":"1.0","type":"link"}