{"product_id":"mechanisms-conferring-robustness-to-erk12-franziska-witzel-9783832541132","title":"Mechanisms Conferring Robustness to Erk1\/2 Signalling","description":"T\u003cb\u003eMechanisms Conferring Robustness to Erk1\/2 Signalling\u003c\/b\u003e  Aby Franziska Witzel  DOn the molecular scale even clonal cells do not look alike, as gene expression is inherently stochastic and in consequence protein levels fluctuate. Cellular signal transduction pathways are affected by this gene expression noise, as proteins relay information about the environment to the nucleus, ultimately regulating cell fate decisions. So how can signalling work in a reliable and reproducible fashion? A combination of experiments and mathematical modelling reveals how negative feedbacks and phosphorylation cycles create the remarkable robustness of MAPK signalling when the concentration of Erk1\/2 is increased or reduced by targeted perturbations.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Franziska Witzel\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3832541136\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783832541132\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Logos Verlag Berlin\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 11\/05\/2015\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 172\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback","brand":"Franziska Witzel","offers":[{"title":"Paperback","offer_id":48450134540543,"sku":"9783832541132","price":65.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_81d5dd3d-7360-4c2c-9b4d-2dc09fff7162.jpg?v=1777266361","url":"https:\/\/www.whiterainbookhouse.com\/products\/mechanisms-conferring-robustness-to-erk12-franziska-witzel-9783832541132","provider":"WR Book House","version":"1.0","type":"link"}