{"product_id":"medicinal-chemistry-sunitha-n-9786206142058","title":"Medicinal chemistry","description":"SYNTHESIS AND CHARACTERIZATION OF 3,5- DIMETHYL PYRAZOLEAIM: To synthesize 3,5- dimethyl pyrazole in the laboratory and characterize the crude and re-crystallized product.APPARATUS\/INSTRUMENT REQUIRED: Reflux condenser, round bottomed flask, beaker, glass rod, pipette, buchner funnel, filtering flask, water bath, watch glass, capillary tube, thiele's tube, thermometer, electronic balance, vacuum pump and filter paper.CHEMICALS REQUIRED: Acetyl acetone, hydrazine hydrate, ethyl alcohol and n-hexane\/petroleum ether.CHEMICAL REACTION: REACTION MECHANISM: PRINCIPLE: Substituted pyrazoles are prepared by condensation of 1,3-diketones with hydrazine. For example, acetyl acetone and hydrazine gives 3,5-dimethyl pyrazole. The enamine and imine formed undergo cyclization to yield the product.PROCEDURE: 1. Take 0.06 moles of hydrazine hydrate in a 250 ml flask.2. To this, add 25 mL of ethyl alcohol with constant stirring.3. Now place the flask in an ice-old water or ice-bath and wait for 10 minutes.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Sunitha N, Appa Rao B\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 6206142051\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9786206142058\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e LAP Lambert Academic Publishing\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 02\/07\/2023\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 80\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.28lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 9.00h x 6.00w x 0.19d","brand":"Sunitha N","offers":[{"title":"Paperback","offer_id":44121552945407,"sku":"9786206142058","price":47.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_0e68dafc-c0bb-41ad-a5db-35af63dfc243.jpg?v=1687420358","url":"https:\/\/www.whiterainbookhouse.com\/products\/medicinal-chemistry-sunitha-n-9786206142058","provider":"WR Book House","version":"1.0","type":"link"}