{"product_id":"metabolic-engineering-of-basfia-succiniciproducens-jonathan-thomas-fabarius-9783736999138","title":"Metabolic engineering of Basfia succiniciproducens for the production of carbon-three compounds (Band 7)","description":"Beschreibung The recent rise of bio-succinic acid as an industrial platform chemical has brought the rumen bacterium Basfia succiniciproducens, a natural producer of this organic acid, into the focus of research. This work investigated the potential of B. succiniciproducens for the production of carbon-three chemicals from sugars. Beside the optimization of improved genetic tools, the C3 chemicals alanine, β-alanine and 3-hydroxypropionate (3-HP) were targeted. A new alanine producer, B. succiniciproducens ALA-1, exhibited good performance in the bioprocess. The next step demonstrated the proof-of-concept for β-alanine synthesis using the heterologous expression of aspartate 1 decarboxylase genes from Corynebacterium glutamicum or Vibrio natriegens. The expression of two additional genes enabled the de novo synthesis of up to 100 mg L-1 3-HP from glucose.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eAuthor:\u003c\/b\u003e Jonathan Thomas Fabarius\u003cbr\u003e\u003cb\u003eISBN-10:\u003c\/b\u003e 3736999135\u003cbr\u003e\u003cb\u003eISBN-13:\u003c\/b\u003e 9783736999138\u003cbr\u003e\u003cb\u003ePublisher:\u003c\/b\u003e Cuvillier\u003cbr\u003e\u003cb\u003eLanguage:\u003c\/b\u003e English\u003cbr\u003e\u003cb\u003ePublished:\u003c\/b\u003e 12\/06\/2018\u003cbr\u003e\u003cb\u003ePages:\u003c\/b\u003e 144\u003cbr\u003e\u003cb\u003eFormat:\u003c\/b\u003e Paperback\u003cbr\u003e\u003cb\u003eWeight:\u003c\/b\u003e 0.40lbs\u003cbr\u003e\u003cb\u003eSize:\u003c\/b\u003e 8.27h x 5.83w x 0.31d","brand":"Jonathan Thomas Fabarius","offers":[{"title":"Paperback","offer_id":48446312218879,"sku":"9783736999138","price":52.3,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0662\/2982\/9887\/files\/img_2b83e853-71d7-4738-9c45-6724c2ef8105.jpg?v=1777223855","url":"https:\/\/www.whiterainbookhouse.com\/products\/metabolic-engineering-of-basfia-succiniciproducens-jonathan-thomas-fabarius-9783736999138","provider":"WR Book House","version":"1.0","type":"link"}